• rRNA modification by the thiostrepton-resistance methyltransferase (Tsr)

  • Molecular mechanisms of RNA-mediated regulation of OAS1

  • Structural studies of aminoglycoside-resistance rRNA methyltransferases

Contact

Graeme L. Conn, Ph.D.
Associate Professor
Department of Biochemistry
O. Wayne Rollins Rsch. Center
1510 Clifton Rd. NE
Atlanta, GA 30322

4135 Office
4178 Lab
404.727.5965 (Office tel.)
404.712.0058 (Lab tel.)
404.727.2738 (Fax)
gconn@emory.edu

ORCiD
Research Gate

Overview

We use modern biochemical and biophysical methods to study the structures, interactions and biological functions of biomedically important RNA and protein molecules. Current topics include mechanisms of bacterial antibiotic resistance that arise through ribosomal RNA modification and non-coding RNA-mediated pathogen evasion of host cell innate immune responses.

Interested in joining the Conn Lab? Current openings for Postdocs and Staff, and details on how to apply, are posted here. Graduate students may also contact Dr. Conn directly but should make applications via the Graduate Division (GDBBS). Dr. Conn is a training faculty member of the BCDB and MMG graduate programs.

Funding

Our research is currently funded by NIH/NIAID grant R01-AI088025.

Research Highlights

Congratulations to Emily Kuiper who was named the Biochemistry, Cell and Developmental Biology (BCDB) Graduate Program Scholar of the Year for 2015! Emily is pictured below receiving her award from Graduate Division Director Dr. Keith Wilkinson.

Emily Kuiper award

Latest News

  • August 2015, Fellowship Award: BCDB graduate student Brenda Calderon was awarded a fellowship from the ARCS Foundation. Congratulations Brenda!
  • August 2015, Farewell: Research Specialist Sam Schwartz leaves the lab to start Grad School in the Biochemistry, Cell and Developmental Biology (BCDB) Program at Emory. Good luck Sam! 

  • September 2015, GDBBS Award: Emily Kuiper is named the Biochemistry, Cell and Developmental Biology (BCDB) Graduate Program Scholar of the Year for 2015 - congratulations Emily!

  • September 2015, Farewell: Visiting PhD student Laís Corrêa returns to Brazil to complete her PhD at the Universidade Federal do Rio de Janeiro. 

  • October 2015, Paper Published: Our paper on the thiostrepton-resistance methyltransferase Tsr in collaboration with Prof. John Honek’s group is published in FEBS Letters. Congratulations to Cullen Myers (Honek Lab) and second author Emily Kuiper!

  • November 2015, Paper Accepted: Laís Corrêa’s paper on the pathogen-derived m7G1405 aminoglycoside-resistance methyltransferases is accepted for publication in Antimicrobial Agents and Chemotherapy. Congratulations Laís!

  • November 2015, Paper Accepted: Postdoc Marta Witek’s paper on the aminoglycoside-resistance methyltransferase from C. acidiphilia is accepted for publication in Nucleic Acids Research. Congratulations Marta!

  • November 2015, Paper Published: Our paper on PKR domain and interdomain linker function by co-first authors Sunita Subramanian and Sam Schwartz is published in JBC. Congratulations Sunita and Sam!

  • December 2015, Paper Published: Natalia Zelinskaya’s paper on the unexpected activity of the aminoglycoside-resistance methyltransferase NpmA is published in Antimicrobial Agents and Chemotherapy.

  • December 2015, Paper Accepted: Our paper in collaboration with Joanna Goldberg’s Lab (Emory University) on the P. aeruginosa methyltransferase EftM was accepted for publication in JBC. Congratulations to co-first authors Emily Kuiper and Josh Owings (Goldberg Lab), and everyone else involved!

  • December 2015, Farewell: Postdoc Marta Witek leaves the lab to start her position as a Research Scientist at Eli Lilly. Good luck Marta – we’ll miss you!