• rRNA modification by the thiostrepton-resistance methyltransferase (Tsr)

  • Molecular mechanisms of RNA-mediated regulation of OAS1

  • Structural studies of aminoglycoside-resistance rRNA methyltransferases

Contact

Graeme L. Conn, Ph.D.
Associate Professor
Department of Biochemistry
O. Wayne Rollins Rsch. Center
1510 Clifton Rd. NE
Atlanta, GA 30322

4135 Office
4178 Lab
404.727.5965 (Office tel.)
404.712.0058 (Lab tel.)
404.727.2738 (Fax)
gconn@emory.edu

ORCiD
Research Gate

Overview

We use modern biochemical and biophysical methods to study the structures, interactions and biological functions of biomedically important RNA and protein molecules. Current topics include mechanisms of bacterial antibiotic resistance that arise through ribosomal RNA modification and non-coding RNA-mediated pathogen evasion of host cell innate immune responses.

Interested in joining the Conn Lab? Current openings for Postdocs and Staff, and details on how to apply, are posted here. Graduate students may also contact Dr. Conn directly but should make applications via the Graduate Division (GDBBS). Dr. Conn is a training faculty member of the BCDB and MMG graduate programs.

Funding

Our research is currently funded by NIH/NIAID grant R01-AI088025.

Research Highlights

Congratulations to Emily Kuiper who defended her PhD thesis in July 2016! Emily is pictured below with former Graduate Division Director Dr. Keith Wilkinson receiving her award for the BCDB Graduate Program Scholar of the Year for 2015.

Emily Kuiper award

Latest News

  • January 2016, Paper Published: Laís Corrêa’s paper on the pathogen-derived m7G1405 aminoglycoside-resistance methyltransferases is published in Antimicrobial Agents and Chemotherapy. Congratulations Laís!
  • January 2016, Paper Published: Postdoc Marta Witek’s paper on the aminoglycoside-resistance methyltransferase from C. acidiphilia is published in Nucleic Acids Research. Congratulations Marta!
  • January 2016, Review Article Published: Former graduate student Ginny Vachon’s review on adenovirus VA RNAI is published in Virus Research.
  • February 2016, Paper Published: Our paper in collaboration with Joanna Goldberg’s Lab (Emory University) on the P.aeruginosa methyltransferase EftM is published in the JBC. Congratulations to co-first authors Emily Kuiper and Josh Owings (Goldberg Lab), and everyone else involved!
  • April 2016, New Lab Member: BCDB graduate student Samantha Schwartz joins the lab – welcome (back) Sam!
  • July 2016, New Award: Graduate student Sam Schwartz is appointed to the BCDB Program’s NIH T32 training grant. Congrats Sam! TG
  • July 2016, Thesis Defense: BCDB graduate student Emily Kuiper successfully defended her PhD thesis. Congratulations Dr. Kuiper!