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The other notable feature of intracellular
proteolysis is its requirement for cellular energy. Since proteolysis
is an exergonic reaction, the only reason to use energy is to
control specificity (i.e., which proteins get degraded, when and
where.)
The energy of ATP is utilized in two ways:
---->to maintain a separate compartment containing the proteolytic enzymes.
---->to deliver the substrate proteins to that compartment for degradation.
Catabolism
of intracellular protein: molecular aspects. Beynon RJ;
Bond JS . Am J Physiol 251: C141-52 (1986).
Selective
binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate
dehydrogenase by isolated rat liver lysosomes. Cuervo AM;
Terlecky SR; Dice JF; Knecht E. J Biol Chem 269: 26374-80
(1994).
Regulation
of selective protein degradation in the endoplasmic reticulum
by redox potential. Young J; Kane LP; Exley M; Wileman
T. J Biol Chem 268: 19810-8 (1993).
The
ubiquitin-mediated proteolytic pathway: mechanisms of recognition
of the proteolytic substrate and involvement in the degradation
of native cellular proteins. Ciechanover A; Schwartz AL.
FASEB J 8: 182-91 (1994).