How does the cell know which proteins to degrade, and when?

TARGETING SIGNALS

Gilon T, Chomsky O, Kulka RG.

Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair.
Mol Cell Biol. 2000 Oct;20(19):7214-9.
PMID: 10982838; UI: 20440181

Sommer T, Wolf DH.

Endoplasmic reticulum degradation: reverse protein flow of no return.
FASEB J. 1997 Dec;11(14):1227-33. Review.
PMID: 9409541; UI: 98072199

Galan JM, Cantegrit B, Garnier C, Namy O, Haguenauer-Tsapis R.

'ER degradation' of a mutant yeast plasma membrane protein by the ubiquitin-proteasome pathway.
FASEB J. 1998 Mar;12(3):315-23.
PMID: 9506475; UI: 98165300

Hiller MM, Finger A, Schweiger M, Wolf DH.

ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway.
Science. 1996 Sep 20;273(5282):1725-8.
PMID: 8781238; UI: 96376607

Kornitzer D, Ciechanover A.

Modes of regulation of ubiquitin-mediated protein degradation.
J Cell Physiol. 2000 Jan;182(1):1-11. Review.
PMID: 10567911; UI: 20036603

Sommer T, Seufert W.

Genetic analysis of ubiquitin-dependent protein degradation.
Experientia. 1992 Feb 15;48(2):172-8. Review.
PMID: 1740189; UI: 92155312

Johnson ES, Ma PC, Ota IM, Varshavsky A.

A proteolytic pathway that recognizes ubiquitin as a degradation signal.
J Biol Chem. 1995 Jul 21;270(29):17442-56.
PMID: 7615550; UI: 95340540

Sadis S, Atienza C Jr, Finley D.

Synthetic signals for ubiquitin-dependent proteolysis.
Mol Cell Biol. 1995 Aug;15(8):4086-94.
PMID: 7623804; UI: 95349574

Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM.

The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.
Mol Cell. 2000 Aug;6(2):409-19.
PMID: 10983987; UI: 20437281

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Molinari E, Gilman M, Natesan S.

Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo.
EMBO J. 1999 Nov 15;18(22):6439-47.
PMID: 10562555; UI: 20031654