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September 2013: Lahcen Jaafar, Research Associate in  the Dynan Laboratory, recently published a first-author paper in PloS One entitled, “Long-term effects of ionizing radiation oLahcen figuren gene expression in a zebrafish model.” Results indicated that single, low-dose developmental exposure to γ-rays affects the expression levels for hundreds of genes that are unaffected in the acute radiation response. The work further develops zebrafish as a genetically tractable model for addressing mechanisms by which radiation injury translates into long-term effects. 

Lahcen also recently published a joint first-author paper in Nucleic Acids Research, entitled, “Receptor-mediated delivery of engineered nucleases for genome modification.” The work describes a method for ligand-mediated delivery of zinc finger nucleases (ZFNs) as protein therapeutics using transferrin receptor-mediated endocytosis. The approach is flexible and general, with the potential for extension to other targeting ligands and nuclease architectures.

September 2013: Candela Manfredi has joined the Dynan laboratory as a postdoctoral fellow. Originally from Argentina, Candela earned her PhD at the Centro Nacional de Biotecnología-CSIC in Madrid and was a postdoctoral fellow in the laboratory of Peggy Hsieh at the National Institutes of Health. She will be working on methods to inhibit DNA double-strand break repair or alter repair pathway choice in normal and tumor cells.

February 2014: Feng-jue Shu, Ph.D., has joined the Dynan laboratory as a Research Specialist, Lead.