Dunham Lab Publications


24. Dunkle JA, Dunham CM (2015). Mechanisms of mRNA frame maintenance and its subversion during translation of the genetic code. Biochimie. epub 2015 Feb 21. [download PDF].


23. Fagan CE, Maehigashi T, Dunkle JA, Miles SJ and Dunham CM (2014). Structural insights into translational recoding by frameshift suppressor tRNASufJ. RNA. 20(12):1944-54. [download PDF]

22. Washington AZ, Benicewicz DB, Canzoneri JC, Fagan CE, Mwakwari SC, Maehigashi T, Dunham CM*, Oyelere AK* (2014). Macrolide-peptide conjugates as probes of the path of travel of the nascent peptides through the ribosome. ACS Chem Biol. 9(11):2621-31.PMID: 25198768. (PMCID in process) *These authors contributed equally. [download PDF

21. Maehigashi T#, Dunkle JA#, Miles SJ and Dunham CM (2014). Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem-loops. Proc Natl Acad Sci, 111(35):12740-5. PMCID: PMC4156745. #These authors contributed equally. [download PDFLink to LabLand: Emory Health Sciences Research Blog

20. Ruangprasert A#, Maehigashi T#, Miles SJ, Giridharan N, Liu JX and Dunham CM (2014). Mechanisms of toxin inhibition and transcriptional repression by E. coli DinJ-YafQ. Journal of Biological Chemistry, 289(30):20559-69. PMCID: PMC4110269. [download PDF] #These authors contributed equally.

19. Schureck MA and Dunham CM (2014). Bacterial warfare again targets the ribosome. 6;22(5):661-2. Structure. PMID: 24807074. [download PDF]

18. Dunkle JA, Vinnal K, Desai PM, Zelinskaya N, Savic M, West DM, Conn GL* and Dunham CM* (2014). Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. Proc Natl Acad Sci, 111(17):6275-80. PMCID: PMC4035980. [download PDF] Link to LabLand: Emory Health Sciences Research Blog *Co-corresponding authors.

17. Cruz JW#, Rothenbacher FP#, Maehigashi T, Lane WS, Dunham CM, Woychik NA (2014). Doc toxin is a kinase that inactivates elongation factor Tu. Journal of Biological Chemistry 289(11):7788-98. PMCID: PMC3953291. [download PDF#These authors contributed equally.

16. Schureck MA, Maehigashi T, Miles SJ, Marquez J, Ei Cho S, Erdman R and Dunham CM (2014). Structure of the P. vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex. Journal of Biological Chemistry, 289(2):1060-70. PMCID: PMC3887174. [download PDF]


15. Fagan CE, Dunkle JA, Maehigashi T, Dang MN, Deveraj A, Miles SJ, Qin D, Fredrick K and Dunham CM (2013). Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state. Proc Natl Acad Sci, 110(24):9716-21. PMCID: PMC3683721 [download PDF][download commentary]

14. Jones BL, VanLoozen J, Kim MH, Miles SJ, Dunham CM, Williams LD and Snell TW (2013). Stress granules form in Brachionus manjavacas (Rotifera) in response to a variety of stressors. Comp Biochem Physiol A Mol Integr Physiol. 166(2):375-84. PMID: 23856158. [download PDF]


13. Meisner J#, Maehigashi T#, André I, Dunham CM*, Moran CP Jr* (2012). Structure of the basal components of a bacterial transporter. Proc Natl Acad Sci, 109(14):5446-51. PMCID: PMC3325725. [download PDF#These authors contributed equally. *Co-corresponding authors


12. Leung SW, Apponi LH, Cornejo OE, Kitchen CM, Valentini SR, Pavlath GK, Dunham CM, Corbett AH (2009). Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein. Gene439(1-2):71-8. PMCID: PMC2680464. [download PDF]

11. Neubauer C# Gao Y-G#, Andersen KR#, Dunham CM, Kelley AC, Hentschel J, Gerdes K Ramakrishnan V, and Brodersen DE (2009). The structural basis for mRNA recognition and cleavage by the ribosome-dependent endonuclease RelE. Cell, 139(6): 1084-1095. PMCID: PMC2807027. [download PDF] #These authors contributed equally.

10. Gao Y-G, Selmer M, Dunham CM, Weixlbaumer A,  Kelley AC, Ramakrishnan V (2009). The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State. Science, 326(5953): 694-99. PMCID: PMC3763468. [download PDF]

2005 - 2007

9. Weixlbaumer A, Petry S#, Dunham CM#, Selmer M#, Kelley AC and Ramakrishnan V (2007). Crystal structure of the ribosome recycling factor bound to the ribosome. Nature Structural Molecular Biology, 14(8): 733-7. PMID: 17660830. [download PDF#These authors contributed equally.

8. Dunham CM and Conn GL (2007). Recombinant RNA expression. Nature Methods, 4(7):547-8. [download PDF]

7. Dunham CM#, Selmer M# Phelps SS, Kelley AC, Suzuki T, Joseph S and Ramakrishnan V (2007). Ribosomal frameshifting in the decoding center of the 30S subunit. RNA, 13(6):817-23. PMCID: PMC1869038. [download PDF#These authors contributed equally.

6. Selmer M#, Dunham CM#, Murphy IV FV, Weixlbaumer A, Petry S, Kelley AC, Weir J and Ramakrishnan V (2006). Structure of the 70S Ribosome Complexed with mRNA and tRNA. Science, 313(5795):1935-42. PMID: 16959973. [download PDF]. Highlighted in the ‘News and Views’ section, Nature Structural & Molecular Biology, 13:864. #These authors contributed equally.

5. Petry S, Broderson DE, Murphy IV FV, Dunham CM, Selmer M, Tarry MJ, Kelley AC and Ramakrishnan V (2005). Crystal structures of release factors RF1 and RF2 bound to a programmed ribosome with a cognate stop codon. Cell, 123(7):1255-66. PMID: 16377566. [download PDF]

2002 - 2003

4. Dunham CM, Murray JB, and Scott WG (2003). A Helical Twist-Induced Conformational Switch Activates Cleavage in the Hammerhead Ribozyme. Journal of Molecular Biology, 332(2):327-36. PMID: 12948485. [download PDF]

3. Dunham CM#, Dioum EM#, Tuckerman JR, Gonzalez G, Scott WG and Gilles-Gonzalez M-A (2003). A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure. Biochemistry, 42(25):7701-7708. [download PDF#These authors contributed equally

2. Murray JB, Dunham CM and Scott WG (2002). A pH-Dependent Conformational Change, Rather than the Chemical Step, Appears to be Rate-Limiting in the Hammerhead Ribozyme Cleavage Reaction.  Journal of Molecular Biology, 315(2):121-130. PMID: 11779233. [download PDF]

1. Burns CS#, Aronoff-Spencer E#, Dunham CM#, Lario P, Avdievich NI, Antholine WE, Olmstead MM, Vrielink A, Gerfen GJ, Peisach J, Scott WG and Millhauser GL (2002). Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein. Biochemistry, 41(12):3991-4001. PMID: 11900542. [download PDF#These authors contributed equally. 

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