The Dunham laboratory studies the structure and function of bacterial protein synthesis. The ribosome is a large macromolecular machine that produces all proteins in every living organism and is the target for half of all clinical antibiotics. Therefore understanding how the ribosome is regulated is a fundamental question in biology.
We study both the canonical function of the ribosome as well as the regulation of translation that results from stress. Major projects include understanding how the ribosome maintains the three nucleotide genetic code during elongation and how bacteria regulate translation in response to diverse ranges of stress. We use a number of interdisciplinary approaches including structural biology, biochemistry, and molecular biology techniques.
We are always interested in recruiting bright, creative and motivated students and postdoctoral fellows to join our research group. If interested, please click here.
July 2018: Congrats to Christine for being selected the 2019 ASBMB Young Investigator!
June 2018: Christine is an invited speaker at the FASEB Machines on Genes Meeting held in Snowmass Village, Colorado.
June 2018: Christine is a plenary speaker at the ASM Microbe meeting held in Atlanta, GA.
May 2018: MSP graduate student Pooja Srinivas joins the lab- welcome!
May 2018: Congrats to grad student Ha An Nguyen for her travel award to attend the RNA Society Meeting held in Berkeley!
April 2018: Congrats to grad student Ha An Nguyen for receiving the Outstanding Teaching Assistant Award!
January 2018: Sam Hong’s paper is published in Structure!
August 2017: Congrats to grad student Ian Pavelich who was awarded an ARCS scholarship!
June 2017: Christine is awarded the American Crystallographic Association Etter Award at the Annual meeting in New Orleans! We are grateful for this recognition!
Mar 2017: Eric Hoffer's paper is published in JBC!
May 2016: Christine is named a Burroughs Wellcome Investigator in the Pathogenesis of Infectious Diseases Awardee. We are very grateful for the support!