The Dunham laboratory studies the structure and function of bacterial protein synthesis. The ribosome is a large macromolecular machine that produces all proteins in every living organism and is the target for half of all clinical antibiotics. Therefore understanding how the ribosome is regulated is a fundamental question in biology.
We study both the canonical function of the ribosome as well as the regulation of translation that results from stress. Major projects include understanding how the ribosome maintains the three nucleotide genetic code during elongation and how bacteria regulate translation in response to diverse ranges of stress. We use a number of interdisciplinary approaches including structural biology, biochemistry, and molecular biology techniques.
We are always interested in recruiting bright, creative and motivated students and postdoctoral fellows to join our research group. If interested, please click here.
September 2017: Christine is promoted to Associate Professor!
August 2017: Congrats to grad student Ian Pavelich who was awarded an ARCS scholarship!
June 2017: Christine is an invited speaker at the 5th Annual Symposium on Structural Biology at the Oklahoma COBRE in Structural Biology Center.
June 2017: Christine is awarded the American Crystallographic Association Etter Award at the Annual meeting in New Orleans! We are grateful for this recognition!
Mar 2017: Congrats to Eric who successfully defended his PhD thesis!
Mar 2017: Eric Hoffer's paper is published in JBC!
Feb 2017: Miki Ruangprasert's paper is published in Mol Micro!
Dec 2016: Grad students Ha An Nguyen and Ian Pavelich join the lab! Welcome!
August 2016: Eric Hoffer's paper in collaboration with the Zaher lab is published in Cell Reports!