The Dunham laboratory studies the structure and function of bacterial protein synthesis. The ribosome is a large macromolecular machine that produces all proteins in every living organism and is the target for half of all clinical antibiotics. Therefore understanding how the ribosome is regulated is a fundamental question in biology.
We study both the canonical function of the ribosome as well as the regulation of translation that results from stress. Major projects include understanding how the ribosome maintains the three nucleotide genetic code during elongation and how bacteria regulate translation in response to diverse ranges of stress. We use a number of interdisciplinary approaches including structural biology, biochemistry, and molecular biology techniques.
We are always interested in recruiting bright, creative and motivated students and postdoctoral fellows to join our research group. If interested, please click here.
April 2016: Christine helps organize the American Society of Biochemistry and Molecular Biology (ASBMB) annual meeting in San Diego, CA.
March 2016: Postdoctoral fellow Jeff Meisner joins the lab- welcome!
March 2016: Marc successfully defends his PhD thesis. Congrats!
March 2016: Grad student Marc is selected as the 2016 Southeastern Regional Access Team (SER-CAT) beamline Young Investigator of the Year! This is an award given to the best manuscript by a graduate student or postdoctoral fellow who uses the SER-CAT X-ray beamline at the Advanced Photon Source in Chicago. Congrats! Marc also gave a seminar at the Emory hosted SER-CAT Annual Meeting.
February 2016: Christine gives a seminar at the RNA Interest Group at the University of Utah.
February 2016: Emory undergraduates Kim Zaldana and Cheston Hussein join the lab- welcome!
November 2015: Christine gives a seminar at National Institute of Diabetes and Digestive and Kidney Diseases at the NIH in Bethesda, MD.
November 2016: Ryan Dikdan joins the lab as a technician- welcome!
October 2015: Grad student Marc's manuscript is accepted at PNAS! Congrats!
Congratulations to grad student Marc for publishing his paper in PNAS!
Congratulations to grad student Eric for publishing his model for how VapC interacts with tRNA in Nature Comunications with the Woychik lab!