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Recent Publications (Since 2008)

doi icon pmc icon Marullo, R., Werner, E., Degtyareva, N., Moore, B., Altavilla, G., Ramalingam, S. S. & Doetsch, P. W. (2014). Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions. PLoS One. 8(11):e81162.
doi icon Xie, M., Yen, Y., Owonikoko, T. K., Ramalingam, S. S., Khuri, F. R., Curran, W. J., Doetsch, P. W. & Deng, X. (2014). Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase. Cancer Res. 74(1):212-223.
doi icon Bauer, N. C., Corbett, A. H. & Doetsch, P.W. (2013). Automated quantification of the subcellular localization of multicompartment proteins via Q-SCAn. Traffic. 14(12):1200-1208.
doi icon pmc icon Degtyareva, N. P., Heyburn, L., Sterling, J., Resnick, M. A., Gordenin, D. A. & Doetsch, P.W. (2013). Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines. Nucleic Acids Res. 41(19):8995-9005.
doi icon pmc icon Morreall, J. F., Petrova, L., & Doetsch, P. W. (2013). Transcriptional mutagenesis and its potential roles in the etiology of cancer and bacterial antibiotic resistance. J. Cell. Physiol. 228(12):2257-2261.
pmc icon Zhaozhong, L., Owonikoko, T. K., Sun, S.-Y., Ramalingam, S. S., Doetsch, P. W., ZXiao, Z.-Q., Khuri, F. R., Curran, W. J., & Deng, X. (2012). c-Myc suppression of DNA double-strand break repair. Neoplasia. 14(12):1190-1202.
doi icon Swartzlander, D. B., Bauer, N. C., Corbett, A. H. & Doetsch, P. W. (2012). Regulation of base excision repair in eukaryotes by dynamic localization strategies. Prog. Mol. Biol. Trans. Sci. 110:93-121.
doi icon pmc icon Zhang, X., Ng, W. L., Wang, P., Tian, L., Werner, E., Wang, H., Doetsch, P. & Wang, Y. (2012). MicroRNA-21 modulates the levels of reactive oxygen species levels by targeting SOD3 and TNF. Cancer Res. 72(18):4707-4713
doi icon pmc icon Morris, L. P., Degtyareva, N., Sheppard, C., Heyburn, L., Ivanov, A. A., Kow, Y. W. & Doetsch, P. W. (2012). Saccharomyces cerevisiae Apn1 mutation affecting stable protein expression mimics catalytic activity impairment: implications for assessing DNA repair capacity in humans. DNA Repair 11(9):753-765.
doi icon pmc icon Rowe, L. A., Degtyareva, N. P. & Doetsch, P. W. (2012). Yap1: A DNA damage responder in Saccharomyces cerevisiae. Mech. Aging Dev. 133(4):147-156.
doi icon pmc icon Brégeon, D. & Doetsch, P. W. (2011). Transcriptional mutagenesis: causes and involvement in tumour development. Nat. Rev. Cancer 11(3):218-227.
doi icon pmc icon Swartzlander, D. B., Griffiths, L. M., Lee, J., Degtyareva, N. P., Doetsch, P. W. & Corbett, A. H. (2010). Regulation of base excision repair: Ntg1 nuclear and mitochondrial dynamic localization in response to genotoxic stress. Nucleic Acids Res. 38(12):3963-3974.
doi icon pmc icon Clauson, C. L., Saxowsky, T. T. & Doetsch, P. W. (2010). Dynamic flexibility of DNA repair pathways in growth arrested Escherichia coli. DNA Repair 9(7):842-847.
doi icon pmc icon Clauson, C. L., Oestreich, K. J., Austin, J. W. & Doetsch, P. W. (2010). Abasic sites and strand breaks in DNA cause transcriptional mutagenesis in Escherichia coli. Proc. Natl. Acad. Sci. USA 107(8):3657-3662.
doi icon pmc icon Pawar, V., Jingjing, L., Patel, N., Kaur, N., Doetsch, P. W., Shadel, G. S., Zhang, H. & Siede, W. (2009). Checkpoint kinase phosphorylation in response to endogenous oxidative DNA damage in repair-deficient stationary-phase Saccharomyces cerevisiae. Mech. Ageing Dev. 130(8):501-508.
doi icon pmc icon Griffiths, L. M., Swartzlander, D., Meadows, K. L., Wilkinson, K. D., Corbett, A. H. & Doetsch, P. W. (2009). Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress. Mol. Cell. Biol. 29(3):794-807.
doi icon Griffiths, L. M., Doudican, N. A., Shadel, G. S. & Doetsch, P. W. (2009). Mitochondrial DNA oxidative damage and mutagenesis in Saccharomyces cerevisiae. Methods Mol. Biol. 554:267-286.
doi icon pmc icon Saxowsky, T. T., Meadows, K. L., Klungland, A. & Doetsch, P. W. (2008). 8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells. Proc. Natl. Acad. Sci. USA 105(48):18877-82.
doi icon pmc icon Rowe, L. A., Degtyareva, N. & Doetsch, P. W. (2008). DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae. Free Radical Biol. Med. 45(8):1167-1177.
doi icon pmc icon Degtyareva, N. P., Chen, L., Mieczkowski, P., Petes, T. D. & Doetsch, P. W. (2008). Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae. Mol. Cell. Biol. 28(17):5432-5445.

Key Publications (Before 2008)

doi icon pmc icon Doudican, N. A., Song, B., Shadel, G. S. & Doetsch, P. W. (2005). Oxidative DNA damage causes mitochondrial genetic instability in Saccharomyces cerevisiae. Mol. Cell. Biol. 25(12):5196-5204.
doi icon Evert, B. A., Salmon, T. B., Song, B., Liu, J. J., Siede, W. & Doetsch, P. W. (2004). Spontaneous DNA damage in Saccharomyces cerevisiae elicits phenotypic properties similar to cancer cells. J. Biol. Chem. 279(21):22585-22594.
doi icon Bregeon, D., Doddridge, Z., You, H. J., Weiss, B. & Doetsch, P. W. (2003). Transcriptional mutagenesis induced by uracil and 8-oxoguanine in Escherichia coli. Mol. Cell. 12(4):959-970.
doi icon Viswanathan, A., You, H. J. & Doetsch, P. W. (1999). Phenotypic change caused by transcriptional bypass of uracil in non-dividing cells. Science. 284(5411):159-162.
pmc icon Swanson, R. L., Morey, N. J., Doetsch, P. W. & Jinks-Robertson, S. J. (1999). Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. Mol. Cell. Biol. 19(4):2929-2935.
doi icon Klungland, A., Möss, M., Gunz, D., Constantinou, A., Clarkson, S. G., Doetsch, P. W., Bolton, P. H., Wood, R. D., & Lindahl, T. (1999). Base excision repair of oxidative DNA damage activated by XPG protein. Mol. Cell. 3(1):33-42.
doi icon pmc icon Zhou, W., Reines, D. & Doetsch, P. W. (1995). T7 RNA polymerase bypass of large gaps on the template strand reveals a critical role of the non-template strand in elongation. Cell. 82(4):577-585
pmc icon Freyer, G. A., Davey, S., Ferrer, J. V., Martin, A. M., Beach, D. & Doetsch, P. W. (1995). An alternative eukaryotic excision repair pathway. Mol. Cell. Biol. 15(8):4572-4577.