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Paul W. Doetsch headshot

Paul W. Doetsch, Ph.D.

  • Professor; Distinguished Chair in Cancer Research; Associate Director for Basic Research, Winship Cancer Institute
  • Departments of Biochemistry, Radiation Oncology, and Hematology and Medical Oncology

Dr. Doetsch obtained his doctoral training in nucleic acids biochemistry in the laboratory of Dr. Robert Suhadolnik at Temple University School of Medicine. He then conducted postdoctoral work as a NIH NRSA recipient at the Dana Farber Cancer Institute, Harvard Medical School in the laboratory of Dr. William Haseltine. Dr. Doetsch has been a faculty member engaged in basic cancer research at Emory since 1985. He has been associated with the Winship Cancer Institute of Emory University and the leadership and development of its scientific programs for many years. He is the Program Director of a Program Project Grant, "Cellular Responses to Oxidative Stress in Models of Colon Cancer Development" and has a long track record of R01 grant support from the NCI. Dr. Doetsch has served in the past as a regular member of the Radiation Study Section at the NIH and the Carcinogenesis, Nutrition and Environment study section of the American Cancer Society. He is internationally recognized for his studies and publications in the areas of DNA damage repair, mutagenesis and genetic instability. Over a decade ago, he discovered transcriptional mutagenesis and has been a pioneer in this area and its leading authority. He is the co-editor of a recent (2006) textbook, "DNA Damage Recognition" and has trained dozens of Ph.D. students and postdoctoral fellows. He serves on several important School of Medicine advisory committees, including the Research Advisory Council (RAC).

Natasha Degtyareva headshot

Natasha Degtyareva, Ph.D.

The main goal of my research project is to understand the mechanisms that maintain eukaryotic genome stability. I study different cellular systems that play key roles in the maintenance of the eukaryotic genome: DNA replication, recombination, and repair using Saccharomyces cerevisiae.

Erica Werner headshot

Erica Werner, Ph.D.

I received my Ph.D. in Cell and Molecular Biology from the Catholic University in Santiago, Chile in 1995. From 1997 to 2000, I pursued postdoctoral training in the Laboratory of Zena Werb at UCSF, where I worked on integrin signaling, matrix metalloproteases and inflammation. In June 2000, I moved to Emory and worked in cell adhesion, vesicular traffic and signal transduction related projects in the Department of Cell Biology. In February 2011, I joined the Doetsch Lab to work on the stress response induced by DNA damage in mammalian cells. I'm also involved in studies related to transcriptional mutagenesis in mammalian cells.

Rossella Marullo headshot

Rossella Marullo, M.D.

I received my medical degree from the University of Messina where I also completed my residency in Medical Oncology.

My research focus on oxidative stress response induced by DNA damaging anticancer agents in mammalian cells and how this response can be exploited to improve the efficacy of DNA damaging agents in killing cancer cells.

I am also interested in studying the role of chronic oxidative stress in promoting oncogene-driven carcinogenesis; another major goal of this project is to evaluate how cellular oxidative status influences survival following exposure to DNA damaging agents.

Dan Swartzlander headshot

Dan Swartzlander, Ph.D.

Understanding how the cell responds to threats to its DNA from oxidative stress and other DNA damaging agents is important in determining how an organism is able to protect itself from cancer and other neurodegenerative diseases. Accumulation of reactive oxygen species (ROS), which are produced and primarily found in the mitochondria, leads to a state of oxidative stress in the cell and causes DNA damage. The base excision repair (BER) pathway, which repairs small DNA lesions such as those induced by ROS, has been shown to be involved in repair of both nuclear and mitochondrial DNA. In order to efficiently protect its DNA, either nuclear or mitochondrial, the cell needs to prioritize where its DNA repair enzymes are allocated. The protein Ntg1p which is involved in the recognition of damaged bases and has both N-glycosolase and AP lyase function has been shown through previous work in the lab to localize to both the nucleus and mitochondria where it is involved in BER. I am interested in determining how the localization of Ntg1p is effected by oxidative stress on both the entire cell and in the mitochondria alone and in determining what proteins may be involved in sensing this stress state responsible for reallocating Ntg1p.

Nicholas Bauer headshot

Nicholas Bauer

  • Ph.D. Candidate, Program in Biochemistry, Cell and Developmental Biology
  • nbauer@emory.edu

I graduated in 2008 from Bates College with a B.S. in Biological Chemistry. Living my entire life in the Northeast, I turned south and started my doctoral work in Emory's Biochemistry, Cell and Developmental Biology program, where I took on a joint project with Dr. Paul Doetsch and Dr. Anita Corbett.

My research is an extension of the work by conducted by Dr. Dan Swartzlander and Dr. Lyra Griffiths, then graduate students, which demonstrated that the S. cerevisiae (baker's yeast) base excision repair protein Ntg1 could shift its localization from the nucleus to the mitochondria under genotoxic stresses that shift the balance of damage from one compartment to the other. In support of this work, I have also been developing an automated computer analysis method to quantify protein localization from confocal microscopy images.

Jordan Morreall headshot

Jordan Morreall

I graduated in 2008 with a B.S. in Biology from UNC-Chapel Hill. As a member of the Doetsch lab, I study transcriptional mutagenesis, the process by RNA polymerase bypass of DNA damage creates mutant transcripts. I utilize mammalian and bacterial systems in my research, as well as bioinformatic approaches to study transcriptional mutagenesis across human genomes.

Kristin Limpose headshot

Kristin Limpose

I graduated from Clemson in 2011, majoring in biochemistry, and came to Emory as part of the new Cancer Biology program.

Stacy Holloway headshot

Stacy Holloway, CRA

As a registered Radiologic Technologist, I spent ten years as a Radiographer and then eight years as the Patient Care Coordinator for Interventional Radiology at Emory University Hospital. I was the Patient Relations Coordinator for Emory Healthcare for two years before joining Dr. Doetsch as the Project Administrator for the NIEHS Program Project Grant "Investigation of Cellular Responses to Genotoxic Stress."

Alumni

Postdoctoral Fellows

Years Present Position
1987-1990 Professor and Dean of Science, Georgia Perimeter College
1988-1989 Director of Intellectual and Regulatory Affairs, ProfiGen, Inc.
1989-1991 Associate Professor, Dept. of Biological Sciences, Eastern Kentucky University
1996-1999 Professor, Dept. of Pharmacology, Chosun University
2000-2002 Senior Patent Agent, Life Technologies
2001-2003 Faculty Member, Institute de Génétique Microbienee
2003-2008 Assistant Professor, Chemistry Department, Pacific Lutheran University

Doctoral Graduate Students

Years Program Present Position
1988-1994 Ph.D., Biochemistry Senior Scientific Manager, Genentech, Inc
1988-1995 Ph.D., BMB Associate Professor, Department of Hematology and Medical Oncology, Emory University
1990-1997 Ph.D., BMB Technology Development Specialist, National Institutes of Health
1993-1997 Ph.D., NHS Special Counsel, Sullivan & Cromwell LLP
1995-1999 Ph.D., GMB Lecturer, Department of Microbiology, Miami University
1995-1999 M.D./Ph.D., BMB Assistant Professor of Neurology, Harvard Medical School; Associate Director, Massachusetts General Hospital Telestroke Services; Assistant Neurologist, Massachusetts General Hospital Stroke Research Center and Neurology Clinical Trials Unit
1995-1999 Ph.D., GMB Associate Professor, Department of Neurological Surgery, The Ohio State University College of Medicine
1996-2000 Ph.D., GMB Principal Investigator and Major, U.S. Army Medical Service Corps, Army Institute of Research
1999-2003 Ph.D., GMB Protocol Writer, Duke University Medical Center
1998-2004 Ph.D., Chemistry Research Associate, Vaccine and Gene Therapy Institute of Florida
2000-2004 Ph.D., GMB Research Scientist, PPD, Inc
2000-2004 Ph.D., GMB Senior Patent Agent, Illumina, Inc
2000-2004 Ph.D., GMB Postdoctoral Fellow, New York University
2004-2009 Ph.D., BCDB Postdoctoral Fellow, Centers for Disease Control and Prevention
2004-2009 Ph.D., GMB Postdoctoral Fellow, St. Jude Comprehensive Cancer Center
2004-2010 Ph.D., GMB Postdoctoral Fellow, University of Pittsburg School of Medicine

BCDB: Program in Biochemistry, Cell and Developmental Biology
BMB: Program in Biochemistry and Molecular Biology (precursor to BCDB)
GMB: Program in Genetics and Molecular Biology
NHS: Program in Nutrition and Health Sciences