Graeme L. Conn, Ph.D.
Associate Professor
Department of Biochemistry
O. Wayne Rollins Rsch. Center
1510 Clifton Rd. NE
Atlanta, GA 30322

4135 Office
4178 Lab
404.727.5965 (Office tel.)
404.712.0058 (Lab tel.)
404.727.2738 (Fax)

Research Gate

Recombinant Cover Templeton et al 2011


Our recent publications are listed below. Search PubMed for a complete list of publications related to our work on antibiotic resistance rRNA methyltransferases, or regulation of innate immune proteins (PKR and OAS) by cellular and viral non-coding RNAs. A complete list of Dr. Conn’s publications is also available via My NCBI.


Calderon, B.M. and Conn, G.L. A human cellular noncoding RNA activates the antiviral protein 2’–5’-oligoadenylate synthetase 1. J Biol Chem. 2018 Aug 20. pii: jbc.RA118.004747. doi: 10.1074/jbc.RA118.004747. [Epub ahead of print]. Selected as an Editors' Pick for an upcoming issue in October.


Vinal, K. and Conn, G.L. (2017). Substrate recognition and modification by a pathogen-associated aminoglycoside resistance 16S rRNA methyltransferase. Antimicrob Agents Chemother. 61(5), pii: e00077-17. [PMCID: In progress]

Calderon, B.M. and Conn, G.L. (2017). Human non-coding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR. RNA, 23(4):557-566. [PMCID: PMC5340918]

Witek, M.A.*, Kuiper, E.G.*, Minten, E., Crispell, E.K. and Conn, G.L. (2017). A novel motif for S-adenosyl-L-methionine binding by the ribosomal RNA methyltransferase TlyA from Mycobacterium tuberculosis. J. Biol. Chem. 3;292(5):1977-1987. [PMCID: PMC5290967]

Fasken M.B., Losh J.S., Leung S.W., Brutus S., Avin B., Vaught J.C., Potter-Birriel J., Craig T., Conn G.L., Mills-Lujan K., Corbett A.H., van Hoof A. (2017) Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast. Genetics 205(1):221-237. [PMCID:  PMC5223504]


Kahn, R.A., Conn, G.L., Pavlath, G.K.,  and Corbett A.H. (2016). Use of a Grant Writing Class in Training PhD Students. Traffic, 17(7):803-14. 

Owings, J.P.*, Kuiper, E.G.*, Prezioso, S.M., Meisner, J., Varga, J.J., Zelinskaya, N., Dammer, E.B., Duong, D.M., Seyfried, N.T., Albertí, S., Conn, G.L. and Goldberg, J.B. (2016). Pseudomonas aeruginosa EftM is a thermoresponsive methyltransferase that trimethylates the translation elongation factor-Tu. J. Bio. Chem. 291(7):3280-90. [PMCID: PMC4751374] (*Co-first author)

Witek, M.A. and Conn, G.L. (2016). Functional dichotomy in the 16S rRNA (m1A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization. Nucleic Acids Res. 8(44), 342-353 [PMCID: PMC4705659]

Corrêa, L.L., Witek, M.A., Zelinskaya, N., Picão, R.C., and Conn, G.L. (2016). Heterologous expression and functional characterization of the exogenously acquired aminoglycoside-resistance methyltransferases RmtD, RmtD2 and RmtG. Antimicrob. Agents Chemother. 60(1):699-702 [PMCID: PMC4704232]

Vachon, V.K. and Conn, G.L. (2016). Adenovirus VA RNA: An essential pro-viral non-coding RNA. Virus Res. 212, 39-52.


Myers, C.L., Kuiper, E.G., Grant, P.C., Hernandez, J., Conn, G.L. and Honek, J.F. (2015). Co-substrate binding and enzyme catalysis by the thiostrepton resistance RNA methyltransferase (Tsr) from Streptomyces cyaneus, FEBS Lett. 589(21), 3263-3270. [PMCID: PMC4661090]

Sunita, S.*, Schwartz, S.L.* and Conn, G.L. (2015). The regulatory and kinase domains but not the interdomain linker determine human double-stranded RNA-activated kinase (PKR) sensitivity to inhibition by viral non-coding RNAs. J. Biol. Chem.  290(47), 28156-28165. (*Co-first author) [PMCID: PMC4653674]

Zelinskaya, N., Witek, M.A. and Conn, G.L. (2015). The pathogen-derived aminoglycoside-resistance 16S rRNA methyltransferase NpmA possesses dual m1A1408/m1G1408 specificity. Antimicrob. Agents Chemother. 59(12), 7862-7865. [PMCID: PMC4649141]

Savic, M., Sunita, S., Zelinskaya, N., Desai, P.M., Macmaster, R., Vinal, K. and Conn, G.L. (2015). 30S subunit-dependent activation of the S. cellulosum aminoglycoside resistance-conferring 16S rRNA methyltransferase Kmr. Antimicrob. Agents Chemother. 59(5), 2807-2816. [PMCID: PMC4394793].

Vachon, V.K., Calderon, B.M., and Conn, G.L. (2015). A novel RNA molecular signature for activation of 2'-5' oligoadenylate synthetase-1. Nucleic Acids Res. 43(1), 544-552. [PMCID: PMC4288181]


Hudson, W.H., Pickard, M.R., S. de Vera, I.M., Kuiper, E.G., Mourtada-Maarabouni, M., Conn, G.L., Kojetin, D.J., Williams, G.T. and Ortlund, E.A. (2014). Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate. Nat. Comm. 5, 5395. [PMCID: PMC4280027]

Kuiper, E.G. and Conn, G.L. (2014). Binding induced RNA conformational changes control substrate recognition and catalysis by the thiostrepton-resistance methyltransferase (Tsr). J.Biol.Chem. 289(38), 26189-26200 [PMCID: PMC4176221]

Witek, M.A. and Conn, G.L. (2014). Expansion of the aminoglycoside-resistance 16S rRNA (m1A1408) methyltransferase family: expression and functional characterization of four hypothetical enzymes of diverse bacterial origin. BBA-Proteins Proteom. Biochim Biophys Acta. 1844(9), 1648-1655. [PMCID: PMC4122235]

Wilson*, J.L, Vachon*, V.K., Sunita, S., Schwartz, S.L., and Conn, G.L. (2014).Dissection of the adenoviral VA RNAI Central Domain structure reveals minimal requirements for RNA-mediated inhibition of PKR. J.Biol.Chem289(33), 23233-23245. (*Co-first author) [PMCID PMC4132820]

Dunkle, J.A., Vinal, K., Desai, P.M., Zelinskaya, N., Savic, M., West, D.M., Conn*, G.L. and Dunham*, C.M. (2014). Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. Proc. Natl. Acad. Sci. U.S.A. 111(17), 6275-6280. [PMCID: PMC4035980] (*Co-corresponding author)