Welcome to the Conn Lab
We use modern biochemical and biophysical methods to study the structures, interactions and biological functions of biomedically important RNA and protein molecules. Current topics include mechanisms of bacterial antibiotic resistance that arise through ribosomal RNA modification and drug efflux systems, and RNA-mediated regulation of host cell innate immune responses.
Research Highlights
Congratulations to recent graduate Dr. Sarah Strassler (and colleagues in the Conn and Jackman labs!) on her recent publication on tRNA recognition by Trm10 in JBC! Read more here.
Our latest collaborative study with the Dunham Lab (Emory, Chemistry) defining the molecular basis of 30S subunit recognition and modification by the m7G1405 aminoglycoside-resistance 16S rRNA methyltransferases is out in PNAS. Congrats to first author Dr. Pooja Srinivas (recent grad of the Dunham lab) and everyone else involved! Read more here.
Now out in npj Antimicrobials and Resistance: our latest on the RND efflux system MexXY-OprM. Congratulations to co-first authors Logan Kavanaugh (Conn lab) and Andrew Mahoney (Wuest lab, Emory Chemistry) and everyone else involved! Read more here.
