A list of
session topics and speakers is displayed below (discussion leaders
are noted in italics).
Program at a Glance [pdf]
Program
[pdf]
Saturday, May 15, 2010
2:00 – 6:00 PM - Arrival, registration (Buckhead Foyer),
lower lobby
7:00 - 7:30 PM Welcome reception (East Terrace, 3rd floor)
7:30 - 9:30 PM Welcome dinner
Sunday, May 16, 2010
*Daily breakfast will be held in the Grand Ballroom III, lower
lobby
8:30 – 9:30 AM Keynote Address: Alan D’Andrea (Harvard
Medical School, USA)(S1), “Profiling DNA Repair Pathways
in Human Disease”.
9:30 – 10:30 AM Session I: Therapeutic exploitation of DNA
damage management systems. Speakers: Andrew Minn (Univ. of Pennsylvania,
USA)(S2), “Gene Expression Signatures That Predict and Promote
Resistance to DNA Damage”; David Wilson III (National Institute
on Aging, USA)(S3), “Targeting Base Excision Repair with
Small Molecule Inhibitors”.
10:30 – 10:45 AM Coffee Break
10:45 – 12:10 PM Session II: Double strand break repair I.
Speakers: Simon Powell (Memorial Sloan Kettering Cancer Center,
USA)(S4), “The BRCA1-BRCA2 Pathway Of Homologous Recombination”;
Susan Lees-Miller (Univ. of Calgary, CAN)(S5), “Structural
and functional insights into the roles of DNA-PKcs in the DNA damage
response”; Ya Wang (Emory Univ., USA)(S6), “Targeting
DNA-PK and ATM with miR-101 Sensitizes Tumors to Radiation”.
12:15 – 1:30 PM Lunch (East Terrace, 3rd floor)
1:30 – 3:00 PM Session III: Physical mechanisms of DNA strand
break formation. Speakers: William Bernhard (Univ. of Rochester,
USA)(S7), “One-Electron Oxidation of DNA by Ionizing Radiation:
Competition Between Base-To-Base Hole-Transfer and Hole-Trapping”;
Tetsuro Majima (Osaka Univ., JPN) (S8), “One-Electron Oxidation
of DNA”; Michael Sevilla (Oakland Univ., USA)(S9), “Holes
and Electrons in DNA: The Role of Prototropic equilibria and Excited
States on Charge Transfer to the Sugar Phosphate Backbone”.
3:00 – 3:30 PM Break
3:30 – 5:00 PM Session IV: Imaging of DNA repair. Speakers:
William Dynan (Medical Coll. of Georgia, USA) (S10), “Use
of a Microirradiator for Real-Time Observation of the DNA Double-Strand
Break Response”; Gisella Taucher-Scholz (GSI – Helmholtzzentrum
fur Schwerionenforschung, DEU) (S11), “Visualization of Radiation
Damage to DNA: The Impact of Localized Ion Irradiation and Microscopic
Imaging”; Anil Mantha (Univ. of Texas, USA) (P22), “Repair
of Radiation-Induced Genome Damage: Collaboration Between Base
Excision and Non-homologous End Joining Repair”.
5:00 – 6:30 PM Poster Session I
Monday, May 17, 2010
9:00 – 10:30 AM Session V: DNA Damage Responses.Speakers:
Junjie Chen (MD Anderson Cancer Center, USA) (S12), “DNA
damage responses”; Akira Yasui (Tohoku Univ., JPN)(S13); “Repair
and Chromatin Factors Required for the Repair of DNA Double-Strand
Breaks in Human Cells”; Jason Parsons (P25), “Molecular
Mechanism Controlling Steady State Levels of Base Excision (Univ.
of Oxford, GBR) Repair Proteins”.
10:30 – 10:45 AM Coffee Break
10:45 – 12:15 PM Session VI: Radical approaches to understanding
DNA radiation damage. Werner Friedland (GSF – Helmholtz Center
for Radiation Protection, DEU) (S14), “Stochastic Modeling
of Radiation Damage To DNA and Its Repair: On the Track Towards
Systems Radiation Biology”; Hooshang Nikjoo (Karolinska Institute,
SWE) (S15), “A Computer Model of DNA Damage-Repair in Human
Cell Nucleus”; Marie Davidkova (Academy of Science, CZE)(S16), “Predicting
Radiation Damage to Specific DNA-Protein Complexes”.
12:15 – 1:30 PM Lunch + Group Photo (East Terrace, 3rd floor)
1:30 – 3:00 PM Session VII: DNA radiation damage chemistry.
Speakers: Miral Dizdaroglu (National Inst. of Standards and Technology,
USA)(S17), “Repair of Radiation-Induced Products of DNA by
the Dna Repair Enzymes NEIL1 and NEIL3”; Peter Dedon (Mass.
Inst. of Technology, USA)(S18), “Sequence-Selectivity in
the Chemistry and Quantity of Radical-Mediated DNA Damage”;
Paul Black (University of Rochester, USA)(P3), “Distribution
of Direct-Type Damage in DNA: The Role of One-Electron Reduced
Cytosine”.
3:00 - 3:30 PM Break
3:30 – 5:00 PM Session VIII: DNA repair inhibitors. Speakers:
Michael Weinfeld (Cross Cancer Inst., CAN)(S19), “Polynucleotide
Kinase/Phosphatase – A Potential Target for Therapy”;
Philip Connell (Univ. of Chicago, USA)(S20), “Screening for
Chemical Compounds That Modulate Homologous Recombinational DNA
Repair”; Kamal Datta (Lombardi Cancer Center, USA)(P31), “Space
Radiation Induces Prolonged Oxidative Stress and Sustained DNA
Damage in Mouse Brain: Implications for Premature Aging”.
5:00 – 6:30 PM Poster Session II
Tuesday, May 18, 2010
9:00 – 10:30 AM Session IX: Double strand break repair II
Speakers: George Iliakis (Univ. of Essen, DEU) (S21), “Backup
Pathways of DNA Double Strand Break Repair by Non-Homologous End
Joining in Cells of Higher Eukaryotes”; Fen Xia (Vanderbilt
Univ., USA)(S22), “BRCA1 orchestrates DNA double-strand break
repair”; Katharine Pawelczak (Indiana Univ. School of Med.,
USA)(P30), “Purification and Characterization of Exo-Nuclease
Free Artemis: Implications for DNA-PK Dependent Processing of DNA
Termini in NHEJ Catalyzed DSB Repair”.
10:30 – 10:45 AM Coffee Break
10:45 – 12:15 PM Session X: Betsy Sutherland Memorial Symposium:
Repair of complex DNA lesions. Speakers: Evelyne Sage (CNRS, FRA)(S23), “Processing
of Multiply Damaged DNA Sites in Yeast S. Cerevisiae”; Peter
O’Neill (Univ. of Oxford, GBR)(S24), “Radiation-Induced
Complex DNA Double Strand Breaks – Cleaning Up The Ends”;
Lynn Harrison (LSU-Shreveport, USA) (S25), “Clustered AP
sites and base damage can be converted to complex double strand
breaks in cells”.
12:15 – 1:30 PM Lunch (East Terrace, 3rd floor)
1:00 - 2:00 PM Planning meeting for 12th IWRDD (Location - To
be determined).
Free Afternoon (excursions to Georgia Aquarium, Carlos Museum,
World of Coca Cola, etc.)
Wednesday, May 19, 2010
9:00 – 10:30 AM Session XI: Microbeams, auger emitters,
and reaction pathways. Speakers: Katsumi Kobayashi (KEK-Photon
Factory, JPN)(S26), “Radiobiological Studies Using The Synchrotron
X-Ray Microbeam Irradiation System At The Photon Factory, Kek”;
H. De Cooman (Ghent University, BEL)(P5), “Direct-Effect
Radiation Chemistry of Solid-State Carbohydrates Using EMR and
DFT”; M.A. Hervé du Penhoat (IMPMC, Campus Boucicaut,
Paris, FRA)(P18), Ultrafast Dissociation Of Ionized Biomolecules
In Water: Ab Initio Molecular Dynamics Studies”.
10:30 – 10:45 AM Coffee Break
10:45 – 12:15 PM Session XII: Repair of base damage. Speakers:
Susan Wallace (Univ. of Vermont, USA) (S27), “Repair of DNA
Base Lesions Produced by Ionizing Radiation”; Priscilla Cooper
(Lawrence Berkeley Lab., USA)(S28), “Repair of Oxidative
DNA Base Damage – Regulation in Response to Ionizing Radiation
and Connections to Transcription and Replication”; Mariko
Higuchi (Japan Atomic Energy Agency, JPN)(P19), “Molecular
Dynamics Simulation of Cluster Damaged DNA and hOGG1”.
12:15 – 1:30 PM Lunch (East Terrace, 3rd floor)
1:30 – 3:00 PM Session XIII: Radiation and DNA binding proteins.
Speakers: Hiroshi Ide (Hiroshima Univ., JPN)(S29), “Damage
Response and Repair Mechanisms for DNA-Protein Crosslinks”;
Melanie Spotheim Maurizot (CNRS, FRA)(S30), “Radiation Damage
To DNA Binding Proteins and its Consequences”; Claudio Carra
(Universities Space Research Association, USA)(P17), “Selectivity
and Binding Mechanism of E. Coli DNA Recombinase Protein, A Computational
Approach”.
3:00 – 3:30 PM Break
3:30 – 5:00 PM Session XIV: Young Investigator Award Symposium.
Speakers:
Carlo Vascotto (Univ. of Udine, ITA)(P21), “Criitical Lysine
Residues Within the N-Terminal Domain of APE1 Regulate ITS Biological
Functions”.
Dharmendra Singh (Laboratory of Molecular Gerontology, National
Institute on Aging, USA)(P32), “Physical and Functional Interaction
Between Two Recq Helicases: BLM Helicase And RECQL4”.
Laure Bobyk (Laboratoire des Lesions des Acides Necleiques, FRA)(P2), “Optimisation
of Radosensitizing Effect of Iododeoxyuridine Using Synchrotron
Radiation”.
5:00 - 5:30 PM Closing session and remarks
7:00 PM Banquet
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